1L-6-hydroxymethyl-chiro-inositol 2-(R)-2-O-methyl-3-O-octadecylcarbonate

Uses

A cell permeable, reversible, and substrate competitive phosphatidylinositol ether analog that potently and selectively inhibits Akt (PKB) (IC₅₀ of 5.0 µM). Moderately inhibits PI 3-K activity (IC₅₀ = 83.0 µM). Also inhibits the growth of various cancer cell lines with IC₅₀ values in the 1 - 10 µM range.

Biological Activity

Cell permeable: yes', 'Product competes with ATP.', 'Reversible: yes', 'Target IC50: 5.0 μM for Akt (PKB)