Description
2-
Arachidonyl glycerol (2-
AG) exhibits cannabinoid (CB) agonist activity at the CB
1 receptor,
1 is an important endogenous monoglyceride species,
2 and is thus considered to be the natural ligand for the CB
1 receptor. 2-
AG can also be sequentially metabolized by COX-
2 and specific PG synthases to form PG 2-
glyceryl esters.
3 In activated RAW 264.7 cells, PGD
2 2-
glyceryl ester is the primary product of 2-
AG metabolism in the COX pathway.
3 PGD
2 serinol amide (PGD
2-
SA) is a stable analog of PGD
2 2-
glyceryl ester. Unlike PGD
2 2-
glyceryl ester and other fatty acyl 2-
glyceryl esters, PGD
2-
SA will not isomerize to the less active primary (1-
glyceryl) ester. The biological activity of PGD
2-
SA has not yet been determined.
Definition
ChEBI: PGD2-dihydroxypropanylamine is a prostanoid.
References
1. Sugiura, T., Kodaka, T., Kondo, S., et al.
Is the cannabinoid CB1 receptor a 2-arachidonoylglycerol receptor? Structural requirements for triggering a Ca2+ transient in NG108-15 cells J. Biochem. 122(4),890-895(1997).
2. Kondo, S., Kondo, H., Nakane, S., et al.
2-Arachidonoylglycerol, an endogenous cannabinoid receptor agonist: Identification as one of the major species of monoacylglycerols in various rat tissues, and evidence for its generation through Ca2+-dependent and -independent mechanisms FEBS Lett. 429(2),152-156(1998).
3. Kozak, K.R., Crews, B.C., Morrow, J.D., et al.
Metabolism of the endocannabinoids, 2-arachidonylgycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides J. Biol. Chem. 277(47),44877-44885(2002).
![N-[(2-HYDROXY-1-HYDROXYMETHYL)ETHYL]-11-OXO-9ALPHA,15S-DIHYDROXY-PROSTA-5Z, 13E-DIEN-1-AMIDE Structure](https://www.chemicalbook.com/StructureFile/ChemBookStructure9/GIF/CB3398319.gif)
