Description
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are newly identified endogenous lipids regulated by fasting and high-fat feeding and associated with insulin sensitivity.
1 5-SAHSA is a FAHFA in which stearic acid is esterified to 5-hydroxy stearic acid. The levels of SAHSA are moderately elevated in the serum of glucose tolerant AG4OX mice, which overexpress the Glut4 glucose transporter specifically in adipose tissue.
1 As other FAHFAs improve glucose tolerance, stimulate insulin secretion, and have anti-inflammatory effects, 5-SAHSA may be a bioactive lipid with roles in metabolic syndrome and inflammation.
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References
1. Yore, M.M., Syed, I., Moraes-Vieira, P.M., et al.
Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects Cell 159(2),318-332(2014).
