Uses
This compound undergoes cycloreversion to form the fluoro(hetero)aryl ketene, which undergoes efficient coupling with nucleophiles and allows rapid incorporation of highly fluorinated α-fluoro(hetero)aryl acetic acid derivatives.
General Description
N-Ethyl-
N-isopropylpropan-2-aminium 3-(3-chloro-2,5,6-trifluoropyridin-4-yl)-4-oxo-1,5-dioxaspiro[5.5]-undec-2-en-2-olate is a fluoroarylated-meldrum′s acid adduct. It can be prepared by reacting cyclohexyl-Meldrum′s acid with 3-chloro-2,4,5,6- tetrafluoropyridine.