Description
THP-SS-PEG1-Tos is a cleavable linker containing a THP protecting group and a tosyl end group. Tos is a good leaving group by reacting with nucleophiles, The disulfide bonds can be cleaved by using Dithiothreitol (DTT) reagent.
Uses
THP-SS-PEG1-Tos is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
IC 50
Disulfide Cleavable Linker; Cleavable Linker
References
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:
10.1038/nrd.2016.268
