Description
1-
Palmitoyl lysophosphatidic acid (1-
Palmitoyl LPA) is a LPA analog containing palmitic acid at the
sn-
1 position. LPA binds to one of five different G protein-
coupled receptors (GPCRs) to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility. In addition to playing a role in the aforementioned biological responses, 1-
palmitoyl LPA enhances the action of β-
lactam antibiotics (ampicillin, piperacillin, and ceftazidime) on various strains of
Pseudomonas aeruginosa, a pathogen associated with pulmonary disease and pneumonia,
via binding both Ca
2+ and Mg
2+.
