Description
1-
Palmitoyl lysophosphatidic acid (1-
Palmitoyl LPA) is a LPA analog containing palmitic acid at the
sn-
1 position. LPA binds to one of five different G protein-
coupled receptors (GPCRs) to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility. In addition to playing a role in the aforementioned biological responses, 1-
palmitoyl LPA enhances the action of β-
lactam antibiotics (ampicillin, piperacillin, and ceftazidime) on various strains of
Pseudomonas aeruginosa, a pathogen associated with pulmonary disease and pneumonia,
via binding both Ca
2+ and Mg
2+.
References
[1] KYOKO NOGUCHI Takao S Satoshi Ishii. Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family.[J]. The Journal of Biological Chemistry, 2003, 278 28: 25600-25606. DOI:
10.1074/jbc.m302648200[2] MOOLENAAR W H. LPA: a novel lipid mediator with diverse biological actions.[J]. Trends in Cell Biology, 1994, 4 6: 213-219. DOI:
10.1016/0962-8924(94)90144-9[3] K A KROGFELT. Specific phospholipids enhance the activity of beta-lactam antibiotics against Pseudomonas aeruginosa.[J]. Journal of Antimicrobial Chemotherapy, 2000, 46 3: 377-384. DOI:
10.1093/jac/46.3.377
