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BOC-L-Proline

BOC-L-Proline Structure
BOC-L-Proline
  • CAS No.15761-39-4
  • Chemical Name:BOC-L-Proline
  • CBNumber:CB3274189
  • Molecular Formula:C10H17NO4
  • Formula Weight:215.25
  • MOL File:15761-39-4.mol
BOC-L-Proline Property
  • Melting point: :133-135 °C(lit.)
  • alpha  :-60.5 º (c=1, HAc)
  • Boiling point: :355.52°C (rough estimate)
  • Density  :1.1835 (rough estimate)
  • refractive index  :-60 ° (C=2, AcOH)
  • storage temp.  :Store at RT.
  • solubility  :Soluble in acetic acid.
  • pka :4.01±0.20(Predicted)
  • form  :Crystals or Crystalline Powder
  • color  :White
  • optical activity :[α]20/D 61±2°, c = 2% in acetic acid
  • BRN  :15828
  • InChIKey :ZQEBQGAAWMOMAI-ZETCQYMHSA-N
  • CAS DataBase Reference :15761-39-4(CAS DataBase Reference)
  • EPA Substance Registry System :1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)- (15761-39-4)
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :20/21/22-36/37/38
  • Safety Statements  :24/25-36-26
  • WGK Germany  :3
  • TSCA  :Yes
  • HS Code  :2933 99 80
  • HazardClass  :IRRITANT
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
BOC-L-Proline Price More Price(16)
  • Brand: Sigma-Aldrich
  • Product number: 15490
  • Product name : Boc-Pro-OH
  • Purity: ≥99.0% (T)
  • Packaging: 5g
  • Price: $28.1
  • Updated: 2020/08/18
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 8.53003
  • Product name : Boc-Pro-OH
  • Purity: Novabiochem?
  • Packaging: 25 g
  • Price: $44.6
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 134570
  • Product name : Boc-Pro-OH
  • Purity: 99%
  • Packaging: 25g
  • Price: $72.5
  • Updated: 2020/08/18
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 8.53003
  • Product name : Boc-Pro-OH
  • Purity: Novabiochem?
  • Packaging: 100 g
  • Price: $102
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: B1188
  • Product name : N-(tert-Butoxycarbonyl)-L-proline
  • Purity: >99.0%(T)
  • Packaging: 5g
  • Price: $23
  • Updated: 2021/03/22
  • Buy: Buy

BOC-L-Proline Chemical Properties,Usage,Production

  • Chemical Properties White to off-white microcrystalline powder
  • Preparation Triethylamine (16.5 mL, 0.12 mmol) was added dropwise over a period of 10 min to a stirred, ice-cold suspension of l-proline (10.0 g, 8.7 mmol) in dichloromethane (200 mL) in a 500-mL three-necked, round-bottomed flask. A solution of Boc2O (28.3 g, 0.13 mmol) in dichloromethane (100 mL) was then added over a period of 10 min and the mixture was stirred for 2.5 h. Thereafter, 10% aqueous citric acid (50 mL) was added, and the dichloromethane layer was washed with saturated brine (2×50 mL) and with water (50 mL). After drying the organic phase over magnesium sulfate, the solvent was evaporated and the residue was taken up in hot ethyl acetate. Dilution of this solution with hexane gave the product, N-tertbutoxycarbonyl- L-proline (17.8 g, 95%); mp 138–140℃; TLC (silica gel): Rf=0:36 (EtOAc/MeOH, 1:1).
BOC-L-Proline Preparation Products And Raw materials
Raw materials
Preparation Products
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15761-39-4, BOC-L-ProlineRelated Search:
  • BOC-L-PROLINE-OH
  • BOC-L-PRO
  • L-Proline, N-BOC protected, (2S)-1-(tert-Butoxycarbonyl)pyrrolidine-2-carboxylic acid
  • L-PROLINE-N-T-BOC
  • BOC-L-Proline, 99+% 25GR
  • (S)-1-(tert-buto×ycarbonyl)pyrrolidine-2-carbo×ylic acid N-Boc-L-Proline
  • N-Boc-L-proline Boc-Pro-OH
  • <i>N</i>-(<i>tert</i>-Butoxycarbonyl)-L-proline
  • N-(<i>tert</i>-Butoxycarbonyl)-L-proline
  • (S)-Pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester
  • The BOC-L- pro
  • N-(tert-Butoxycarbonyl)-L-proline, 99.0%(T)
  • Boc-L-Proline SynonyMs N-(tert-Butoxycarbonyl)-L-proline
  • Boc-Pro-OH >=99.0% (T)
  • Daclatasvir Intermediates 3
  • Vildagliptin Impurity 15
  • 1-tert-Butyloxycarbonyl-L-proline
  • (S)-Boc-pyrrolidine-2-carboxylic acid
  • Boc-L-proline≥ 98% (HPLC)
  • TBOC-L-PROLINE
  • T-BUTYLOXYCARBONYL-L-PROLINE
  • RARECHEM AL BO 1463
  • 1,2-PYRROLIDINEDICARBOXYLIC ACID, 1-(1,1-DIMETHYLETHYL) ESTER, (2S)-
  • 1-(tert-butyl) hydrogen (S)-pyrrolidine-1,2-dicarboxylate
  • BOC-L-Proline, 99+%
  • Boc-DL-Proline-OH
  • TERT-BUTYLOXYCARBONYLPROLINE
  • N-ALPHA-T-BUTYLOXYCARBONYL-L-PROLINE
  • N-BOC-PROLINE
  • (2S)-1-tert-butoxycarbonylpyrrolidine-2-carboxylic acid
  • Boc-Pro-OH (Boc-L-Proline
  • N-(tert-Butoxycarbonyl)-L-proline, Boc-L-proline
  • (2S)-1-[(2-Methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
  • Butoxycarbonylproilne
  • N-(tert-Butoxycarbonyl)-L-proline ,98.5%
  • (2S)-1-(tert-Butyloxycarbonyl)pyrrolidine-2α-carboxylic acid
  • (2S)-1,2-Pyrrolidinedicarbonic acid 1-tert-butyl ester
  • (S)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid
  • Boc-Pro-OH (Boc-L-Proline: N-(tert-Butoxycarbonyl)-L-proline)
  • (2S)-Pyrrolidine-2-carboxylic acid, N-BOC protected
  • (S)-1,2-Pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) ester
  • N-(TERT-BUTOXYCARBONYL)-L-PROLINE
  • N-(TERT-BUTOXYCARBONYL)-L-PROILNE
  • N-(TERT-BUTYLOXYCARBONYL)-L-PROLINE
  • N-T-BUTOXYCARBONYL-L-PROLINE
  • N-T-BOC-L-PROLINE
  • N-BOC-L-PROLINE
  • n-alpha-tert-boc-l-proline
  • N-ALPHA-TERT-BUTYLOXYCARBONYL-L-PROLINE
  • N-ALPHA-T-BUTOXYCARBONYL-L-PYRROLIDINE-2-CARBOXYLIC ACID
  • N-ALPHA-T-BUTOXYCARBONYL-L-PROLINE
  • N-ALPHA-T-BOC-L-PROLINE
  • BOC-L-PROLINE extrapure
  • 1-Tert-Butoxycarbonyl-L-proline
  • Boc-L-proline ,98.5%
  • BOC-PYRD(2)-OH
  • BOC-PRO-OH
  • BOC-PRO