Description
Sphinganine is a synthetic bioactive sphingolipid that inhibits the growth of
C. glabrata and
C. albicans with a minimum fungicidal concentration (MFC) value of 0.5 μg/ml for both. More commonly, sphinganine is used as an internal standard in the analysis of sphingoid compounds by chromatographic or spectrometric methods.
Uses
Sphinganine-C17 is found in bovine serum. Sphinganine-C17 is a biomarker for assessment of delayed-type hypersensitivity and response to triptolide.
Definition
ChEBI: Heptadecasphinganine is an aminodiol and a sphingoid.
References
[1] KARIN THEVISSEN . Fungicidal activity of truncated analogues of dihydrosphingosine[J]. Bioorganic & Medicinal Chemistry Letters, 2008, 18 13: Pages 3728-3730. DOI:
10.1016/j.bmcl.2008.05.067[2] STEFKA SPASSIEVA. Combination of C(17) sphingoid base homologues and mass spectrometry analysis as a new approach to study sphingolipid metabolism.[J]. Methods in enzymology, 2007, 434: 233-241. DOI:
10.1016/s0076-6879(07)34012-3[3] FENG QU. Sphingolipids as new biomarkers for assessment of delayed-type hypersensitivity and response to triptolide.[J]. PLoS ONE, 2012: e52454. DOI:
10.1371/journal.pone.0052454
