Description
Cefazolin-
13C
2,
15N is intended for use as an internal standard for the quantification of cefazolin by GC- or LC-MS. Cefazolin is a broad-spectrum cephalosporin antibiotic that is active
in vitro against various Gram-positive and Gram-negative bacteria (MICs = 0.2-12.5 μg/ml). It also inhibits the growth of clinical isolates of
S. aureus, E. coli, P. mirabilis, and
K. pneumoniae (MICs = 0.1-25 μg/ml).
In vivo, cefazolin protects against
S. aureus, E. coli, and
P. mirabilis infection in mice (ED
50s = <0.09-1.78, 0.44-3.63, and 2.31-5.2 mg/animal, respectively). Formulations containing cefazolin have been used to treat a variety of bacterial infections.
