Biological Activity
UNBS5162, an amonafide (naphthalimide) derivative, is a potent antitumor agent th at inhibits tumor proliferation, progression and invasiveness. UNBS5162 is a pan-antagonist of CXCL chemokine expression. It appears th at UNBS5162 inhibits melanoma progression through inhibition of the AKT/mTOR signaling pathway.
References
[1] Mijatovic T, et al. UNBS5162, a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers. Neoplasia. 2008 Jun;10(6):573-86. DOI:
10.1593/neo.08290[2] Tina Mahieu, et al. UNBS5162: A novel naphthalimide derivative with potent pro-autophagic effects in human cancer cells. Cancer Research, 2007 May; 67(9) Supplement.
[3] He D, et al. UNBS5162 inhibits the proliferation of esophageal cancer squamous cells via the PI3K/AKT signaling pathway. Mol Med Rep. 2018 Jan;17(1):549-555. DOI:
10.3892/mmr.2017.7893
