Synthesis
General procedure for the synthesis of 2-(2-pyridyl)-6-chloro-4-amino pyrimidine from 4,6-dichloro-2-(2-pyridyl)pyrimidine: 4,6-dichloro-2-(2-pyridyl)pyrimidine (210 mg, 0.93 mmol) was dissolved in ethanol (2 ml) in a microwave reaction tube. NH4OH (35% aqueous solution, 2.0 ml, 18.58 mmol) was added to this solution. The reaction mixture was heated in a microwave reactor at 100°C for 30 min. After completion of the reaction, the mixture was concentrated under vacuum. Purification was carried out by grinding the residue and washing with isopropanol to afford 2-(2-pyridyl)-6-chloro-4-aminopyrimidine (135 mg, 70% yield).
