Synthesis
Step 2: 5-methoxy-2-nitrobenzamide (9.70 g, 49.4 mmol) was dissolved in methanol (250 mL) and 10% palladium carbon catalyst (2.00 g) was added. The reaction mixture was stirred at room temperature and 1 atmosphere of hydrogen at 1 atmosphere for 6 hours. Upon completion of the reaction, the insoluble material was removed by filtration and the filtrate was concentrated to give 2-amino-5-methoxybenzamide (8.20 g, 99% yield) as a light yellow powder.
References
[1] Patent: EP1953148, 2008, A1. Location in patent: Page/Page column 128-129
[2] Patent: US2015/329556, 2015, A1. Location in patent: Paragraph 1526
[3] Patent: WO2008/54599, 2008, A2. Location in patent: Page/Page column 173
[4] Patent: WO2010/104851, 2010, A1. Location in patent: Page/Page column 168
[5] Patent: WO2006/105081, 2006, A2. Location in patent: Page/Page column 157
