SKF-82958 ((±)-SKF 82958) hydrobromide (0.003-0.1 mg/kg; i.p.) results in dose-dependent increases in responding on the SKF-82958 appropriate lever, with full substitution following administration of the SKF-82958 hydrobromide training dose 0.03 mg/kg. Increasing the dose of SKF-82958 hydrobromide also results in a significant reduction in response rate[2].
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SKF-82958 hydrobromide (0.5-2.0 mg/kg; i.p) significantly suppresses pilocarpine-induced jaw movements[3].
| Animal Model: | Male Sprague-Dawley rats[3] |
| Dosage: | 0.5-2.0 mg/kg |
| Administration: | I.p |
| Result: | Significantly reduced the number of tremulous jaw movements induced by 4.0 mg/kg pilocarpine.
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