Chemical Properties
L-744,832 is White Cyrstalline Solid
Uses
L-744,832 is ras farnesyltransferase inhibitor. Induces tumor regression in transgenic mice with multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis. Induces p21 expressoin and arrests cells at G1. Causes enhanced mitotic
Uses
Ras farnesyltransferase inhibitor. Induces tumor regression in transgenic mice with multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis. Induces p21 expressoin and arrests cells at G1. Causes enhanced mitotic sensitivity to taxol.
General Description
A cell-permeable potent and selective thiol-containing peptidomimetic farnesyltransferase (FTase) inhibitor with anti-tumor properties. Rapidly blocks p70S6K activation and DNA synthesis and promotes apoptosis in transgenic mice. Induces p21 expression and cell cycle arrest in the G
1 phase. Displays synergistic effect with paclitaxel and epothilones in inhibiting tumor growth. Also mimics many of the effects of Rapamycin (Cat. No.
553210) and may be effective against tumors that exhibit inappropriate activation of the mTOR/p70S6K pathway.
Biochem/physiol Actions
Cell permeable: yes
