Biological Activity
MCM7 levels do not vary with cell cycle, but the expression and nascent synthesis of MCM7 occurs late in the cell cycle, coinciding with mitosis. MCM7 immunolocalization may be used as an index of cell proliferation in tissue sections. Monoclonal antibody reacting specifically with MCM7 is also a useful tool in the investigation of the molecular mechanisms behind DNA replication and its restriction to S phase. MCM7 may play a role in normal and neoplastic cell growth. MCM7 favors hepatocellular carcinoma progression.', 'Minichromosome maintenance complex component 7 (MCM7) has been shown to possess DNA helicase activity and is crucial for initiating replication.
