Description
NFAT inhibitor (cell-permeable) is a cell-permeable form of NFAT inhibitor (Item No. 13855), an inhibitor of calcineurin-nuclear factor of activated T cells (NFAT) signaling.1 It inhibits the production of IL-12p40 and nitric oxide (NO) in LPS- and IFN-γ-induced mouse bone marrow-derived macrophages (BMDMs) when used at concentrations of 50 or 100 µM. NFAT inhibitor (cell-permeable) (1 mg/kg) prevents increases in kidney weight and urine albumin levels in a db/db mouse model of diabetic nephropathy.2 It improves fracture healing in a rat model of ovariectomy-induced osteoporosis when administered at a dose of 100 µg/kg for 16 weeks post-fracture.3 NFAT inhibitor (cell-permeable) (1 mg/kg) decreases disease severity in IL-10 knockout mice in a model of colitis induced by piroxicam (Item No. 13368).1WARNING This product is not for human or veterinary use.
References
[1] HOUDA Z ELLOUMI. A cell permeable peptide inhibitor of NFAT inhibits macrophage cytokine expression and ameliorates experimental colitis.[J]. PLoS ONE, 2012: e34172. DOI:
10.1371/journal.pone.0034172[2] LI ZHANG. NFAT2 inhibitor ameliorates diabetic nephropathy and podocyte injury in db/db mice[J]. British Journal of Pharmacology, 2013, 170 2: 426-439. DOI:
10.1111/bph.12292[3] CHANGJU HOU. Peptide 11R‑VIVIT promotes fracture healing in osteoporotic rats.[J]. International journal of molecular medicine, 2021, 48 2. DOI:
10.3892/ijmm.2021.4995
