Synthesis
General Steps:
Example 1: Synthesis of 5-methoxy-2-((4-methoxy-3-methyl-2-pyridinyl)methyl)sulfinyl)-6-methyl-3H-imidazo[4,5-b]pyridine sodium salts [Formula 7
(1a) Synthesis of 2-methoxy-3-methylpyridine [formula 8
2-Fluoro-3-methylpyridine (2.34 g, 21.1 mmol) was mixed with 28% methanol solution of sodium methanolate (7.72 g, 40 mmol) and stirred under reflux conditions for 15 minutes. After completion of the reaction, water was added to the reaction mixture and after neutralization, the organic phase was extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and the solvent was evaporated under reduced pressure to give the title compound (1.62 g, 13.1 mmol, 62%) as a colorless liquid.
1H NMR (400 MHz, DMSO-d6) δ (ppm): 2.13 (3H, s), 3.86 (3H, s), 6.87-6.90 (1H, m), 7.49-7.55 (1H, m), 7.96-8.02 (1H, m).
