Description
C14-A1 is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs).1 LNPs containing C14-A1 and encapsulating mRNA encoding forkhead box protein P3 (FOXP3) increase FOXP3 levels in primary human T cells. LNPs containing C14-A1 and encapsulating mRNA encoding FOXP3 also reduce the proliferation of primary human CD4+/CD8+ T cells, as well increase TGF-β1 and decrease IL-10 secretion from CD4+/CD8+ T cells.WARNING This product is not for human or veterinary use.
References
[1] AJAY S. THATTE, MICHAEL J. MITCHELL* mRNA Lipid Nanoparticles for Ex Vivo Engineering of Immunosuppressive T Cells for Autoimmunity Therapies[J]. Nano Letters, 2023, 23 22: 10179-10188. DOI:
10.1021/acs.nanolett.3c02573
