3-amino-4,5-dihydroxy-5-[[1-(8-hydroxy-1-oxo-isochroman-3-yl)-3-methyl -butyl]carbamoyl]pentanoic acid

Biological Activity

Amicoumacin B is an amicoumacin that has been found in N. jinanensis and has quorum-sensing inhibitory activity.1 It is active against C. violaceum (MIC = 250 μg/ml) and reduces the expression of the C. violaceum operons vioA, vioB, vioD, and vioE, but increases the expression of vioC, indicating quorum sensing inhibitory activity.2 Amicoumacin B increases the expression of bone morphogenetic protein 2 (BMP2) in MG-63 cells.1,3

References

1.Sun, W., Zhang, Y.-Q., Huang, Y., et al.Nocardia jinanensis sp. nov., an amicoumacin B-producing actinomyceteInt. J. Syst. Evol. Microbiol.59(Pt 2)417-420(2009) 2.Shi, W.-P., Zeng, H., Wan, C.-X., et al.Amicoumacins from a desert bacterium: quorum sensing inhibitor against Chromobacterium violaceumNat. Prod. Res.(2020) 3.Zhao-Yong, Y., Zhi-Fei, Z., Xiao-Bo, H., et al.Study on the effect of amicoumacin B on up-regulating bmp-2 transcription and expression in MG63 cellsChin. J. Antibiot.33(4)203-205(2008)