Glycine, N-[2-[(acetyloxy)methoxy]-2-oxoethyl]-N-[4-[[[3',6'-bis(acetyloxy)-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl]carbonyl]amino]-2-methoxyphenyl]-, (acetyloxy)methyl ester

Biological Activity

Thallos AM is a cell-permeable fluorescent thallium indicator that has been used to measure the activity of sodium or potassium channels.1,2 It can also be used for transporters and G protein-coupled receptors (GPCRs). It displays excitation/emission maxima of 490/515 nm, respectively.

References

1.Du, Y., Days, E., Romaine, I., et al.Development and validation of a thallium flux-based functional assay for the sodium channel NaV1.7 and its utility for lead discovery and compound profilingACS Chem. Neurosci.6(6)871-878(2015) 2.Dutter, B.F., Ender, A., Sulikowski, G.A., et al.Rhodol-based thallium sensors for cellular imaging of potassium channel activityOrg. Biomol. Chem.16(31)5575-5579(2018)