Originator
Hemostyptanon,Endopancrine,France,1966
Manufacturing Process
Succinic anhydride and 60 ml of pyridine is heated at 90°C for 4 hours, after which the reaction
mixture is poured into water. The aqueous solution is extracted with ether, the
ether layer is separated, washed with diluted sulfuric acid and after that with
water until neutral, then evaporated to dryness to obtain 14 grams of an
amorphous substance. Melting point 82° to 86°C. This drying residue proves
to consist of a mixture of estriol disuccinate and estriol monosuccinate, which
are separated by repeated crystallization from a mixture of methanol and
water.
