Description
1-
Palmitoyl lysophosphatidic acid (1-
Palmitoyl LPA) is a LPA analog containing palmitic acid at the
sn-
1 position. LPA binds to one of at least five different G protein-
coupled receptors to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility.
1,2 Additionally, 1-
palmitoyl LPA enhances the action of β-
lactam antibiotics (ampicillin, piperacillin, and ceftazidime) on various strains of
P. aeruginosa, a pathogen associated with pulmonary disease and pneumonia,
via binding both Ca
2+ and Mg
2+.
3
Definition
ChEBI: 1-palmitoylglycerol 3-phosphate is a monoacylglycerol phosphate having palmitoyl as the acyl group on O-1 and with the phosphate group on O-3. It is a conjugate acid of a 1-palmitoylglycerol 3-phosphate(2-).
References
1. Noguchi, K., Ishii, S., and Shimizu, T.
Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family J. Biol. Chem. 278(28),25600-25606(2003).
2. Moolenaar, W.H.
LPA: A novel lipid mediator with diverse biological actions Trends Cell Biol. 4(6),213-219(1994).
3. Krogfelt, K.A., Utley, M., Krivan, H.C., et al.
Specific phospholipids enhance the activity of β-lactam antibiotics against Pseudomonas aeruginosa J. Antimicrob. Chemother. 46(3),377-384(2000).
