Sifalimumab
- Product NameSifalimumab
- CAS1006877-41-3
- CBNumberCB28080806
- MW0
- MOL FileMol file
- MSDS FileSDS
Sifalimumab Price
| Product number | Packaging | Price | Product description | Buy |
|---|---|---|---|---|
| ChemScene CS-0612926 | 1mg | $379 | Sifalimumab 99.46% |
Buy |
| ChemScene CS-0612926 | 5mg | $1016 | Sifalimumab 99.46% |
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| ChemScene CS-0612926 | 10mg | $1625 | Sifalimumab 99.46% |
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| aablocks AA0294SD | 1mg | $258 | Sifalimumab |
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| aablocks AA0294SD | 5mg | $643 | Sifalimumab |
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Sifalimumab Chemical Properties,Usage,Production
Uses
Sifalimumab (MEDI-545) is an anti-IFNα monoclonal antibody. Sifalimumab suppresses the abnormal immune activity by binding to multiple interferon-alpha (IFNα) subtypes. Sifalimumab can be used in systemic lupus erythematosus (SLE) research[1][2].in vivo
Sifalimumab (subcutaneous injection; 30 mg/kg and 3 μg/g) treatment shows therapeutic effect and attenuates the lymphocyte infiltration[2].
| Animal Model: | Wild-type male BALB/c mice[2] |
| Dosage: | 30 mg/kg and 3 μg/g |
| Administration: | Subcutaneous injection; 30 mg/kg and 3 μg/g |
| Result: | Prevented the increase CpG-induced, decreasing CD86 fluorescence intensity by 1.9-fold (P < 0.05). Showed a potentially therapeutic effect attenuating the CpG-induced lymphocyte infiltration. Attenuated the CD45 increase (P<0.05). |
References
[1] Merrill JT, et al. Safety profile and clinical activity of sifalimumab, a fully human anti-interferon α monoclonal antibody, in systemic lupus erythematosus: a phase I, multicentre, double-blind randomised study. Ann Rheum Dis. 2011 Nov;70(11):1905-13. DOI:10.1136/ard.2010.144485[2] La Maestra S, et al. Brain microglia activation induced by intracranial administration of oligonucleotides and its pharmacological modulation. Drug Deliv Transl Res. 2018 Oct;8(5):1345-1354. DOI:10.1007/s13346-018-0535-3
Preparation Products And Raw materials
Sifalimumab Suppliers
Global(26)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 15026964105 | 2881489226@qq.com | China | 87240 | 60 | |
| 177-54423994 17754423994 |
2853530910@QQ.com | China | 7996 | 62 | |
| +1-781-999-5354; +1-00000000000 |
marketing@targetmol.com | United States | 32431 | 58 | |
| 15817493340 | 981810490@qq.com | China | 1577 | 58 | |
| 027-65317797 15926423062 |
422450190@qq.com | China | 10302 | 58 | |
| 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 | |
| 4008200310 15002144251 |
marketing@tsbiochem.com | China | 24951 | 58 | |
| 027-65279366 18108604356 |
products@biolabreagent.com | China | 9864 | 58 | |
| 13720134139 086-15871494362 13720134139 |
orders@jknbiochem.com | China | 7284 | 58 | |
| 021-65675885 18964387627 |
customer_service@efebio.com | China | 11963 | 58 |
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