BMP7 Antibody

Source

Rabbit

Applications

BMP7 antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Recommended dilution range for Western blot analysis is 1:500 ~ 2,000. Recommended starting dilution is 1:1,000.

Reactivity

Mouse

Immunogen

IgG Anti BMP-7 has been developed in rabbit using highly pure (>98%) recombinant human BMP-7 expressed in plants.

Background

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.

References

[1] Wang, E.A. et al. (1988) Proc Natl Acad Sci USA 85, 9484-8.
[2] Wozney, J.M. et al. (1988) Science 242, 1528-34.
[3] Kawabata, M. et al. (1998) Cytokine Growth Factor Rev 9, 49-61.
[4] Nohe, A. et al. (2004) Cell Signal 16, 291-9.
[5] Yang, S. et al. (2005) Cancer Res 65, 5769-77.
[6] Alarmo, E.L. et al. (2006) Genes Chromosomes Cancer 45, 411-9.
[7] Motoyama, K. et al. (2008) Ann Surg Oncol 15, 1530-7.
[8] Buijs, J.T. et al. (2007) Cancer Res 67, 8742-91.
[9] Buijs, J.T. et al. (2007) Am J Pathol 171, 1047-57.