Uses
PF-06305591 is an effective and highly selective voltage-gated sodium channel NaV1.8 blocker. It has an IC50 value of 15 nM. It has good preclinical in vitro ADME (absorption, distribution, metabolism and excretion) and safety. It also has a number of therapeutic applications and potential therapeutic applications that can be used to treat pain.
Preparation
A solution of tert-butyl [(1S)-3-amino-1-(5-tert-butyl-1H-benzimidazol-2-yl)-2-methyl-3-oxopropyl]carbamate in DCM and React in TFA, then add saturated NaHCO3 aqueous solution, after treatment, PF-06305591 can be obtained.
