Description
Ac4GlcNAl is an unnatural alkyne-containing monosaccharide building block. The alkyne moiety can be used for modification though chemoselective ligation chemistries including CuAAC or various Pd-catalyzed coupling reactions. The acetyl groups increase solubility in many solvents and make handling of this reagent easier.
Uses
Ac4GlcNAlk is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:
10.1016/j.ebiom.2018.09.005
