CPI-455 Hydrochloride
- Product NameCPI-455 Hydrochloride
- CAS2095432-28-1
- CBNumberCB24672063
- MFC16H15ClN4O
- MW314.77
- MDL NumberMFCD31978193
- MOL File2095432-28-1.mol
Chemical Properties
storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
solubility | ≥31.5 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
Water Solubility | Water: Insoluble |
CPI-455 Hydrochloride Price
Product number | Packaging | Price | Product description | Buy |
---|---|---|---|---|
ApexBio Technology B7811 | 25mg | $320 | CPI-455HCl |
Buy |
ApexBio Technology B7811 | 5mg | $85 | CPI-455HCl |
Buy |
Arctom AS512848 | 10mg | $111 | 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrilehydrochloride ≥98% |
Buy |
Arctom AS512848 | 25mg | $200 | 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrilehydrochloride ≥98% |
Buy |
Arctom AS512848 | 100mg | $349 | 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrilehydrochloride ≥98% |
Buy |
CPI-455 Hydrochloride Chemical Properties,Usage,Production
Biological Activity
cpi-455 is a kdm5 inhibitor.the kdm5 family of histone demethylases catalyzes the demethylation of histone h3 on lysine 4 (h3k4) and is required for the survival of drug-tolerant persister cancer cells (dtps).in vitro
previous study found that cpi-455 could potently inhibit the fulllength kdm5a in enzymatic assays with a half-maximal inhibitory concentration of 10 ± 1 nm. cpi-455 inhibited kdm5a, kdm5b and kdm5c to similar levels but showed significantly weaker potency toward kdm4c and kdm7b (~200- and 770-fold, respectively) and no detectable inhibition of kdm2b, kdm3b or kdm6a. moreover, it was found that the cpi-455-mediated kdm5 inhibition led to a dose-dependent increase in global h3k4me3 in hela cells, and the removal of cpi-455 resulted in a rapid reversal of h3k4me3 increases in hela cells. moreover, cpi-455 could delay the appearance of heavy h3k4me3, which was consistent with the role for kdm5 enzymes in h3k4me3 turnover, however, the turnover of h3k4me2 was only marginally altered. as expected, cpi-455 could affect the turnover of h3k4 monomethylation [1].target
Target | Value |
KDM5A (Cell-free assay) | 10 nM |
IC 50
10 nmReferences
[1] vinogradova m, et al. an inhibitor of kdm5 demethylases reduces survival of drug-tolerant cancer cells. nat chem biol. 2016 jul;12(7):531-8.Preparation Products And Raw materials
CPI-455 Hydrochloride Suppliers
Global(20)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
+1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 32161 | 58 | |
support@targetmol.com | United States | 38631 | 58 | ||
+8618327326525 | masar@topule.com | China | 8467 | 58 | |
+86-18341751992 +86-15382112998 |
757984502@qq.com | China | 892 | 58 | |
+1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 | |
571-89925085 | sales@amadischem.com | China | 131957 | 58 | |
028-81700200 18116577057 |
3003855609@qq.com | China | 7887 | 56 | |
021-52996696,15000506266 15000506266 |
China | 4575 | 55 | ||
021-58447131 13564518121 |
sales@dcchemicals.com | China | 9409 | 58 | |
021-58432009 400-005-6266 |
marketing1@energy-chemical.com | China | 44806 | 58 |
CPI-455 Hydrochloride Spectrum
PROMPT×
PROMPT
The What'sApp is temporarily not supported in mainland China
The What'sApp is temporarily not supported in mainland China
Cancel
Determine