Uses
FITC Conjugated Monoclonal Anti-Human CD4 has been used for:
- identification, quantification and monitoring of helper/inducer T cells in peripheral blood, biological fluids, lymphoid organs, and other tissues
- analysis of T cell mediated cytotoxicity
- characterization of subtypes of T cell leukemias and lymphomas
- studies of T cells in health and disease
- flow cytometry
General Description
CD4, a glycoprotein, is predominantly expressed on the cell membrane of mature, thymus-derived (T) lymphocyte and also to some extent in the monocyte/macrophage lineage. It has a transmembrane domain, cytoplasmic region and an extracellular region of four tandem domain similar like members of Ig superfamily.
Biochem/physiol Actions
Immunoregulatory T cell subset abnormalities in autoimmunity disorders, immunodeficiency diseases, graft versus host disease and following immunosuppressive therapy are often manifested as a change in CD4+/CD8+ ratio in peripheral blood T cells.
