Description
UE2343 (Xanamem) is a potent, orally bioavailable, brain-penetrant 11β-HSD1 inhibitor.
Uses
UE2343 is an orally available, brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor. UE2343 is being investigated for the treatment of Alzheimer's disease[1].
References
[1] Webster S P, et al. Selection and early clinical evaluation of the brain‐penetrant 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) inhibitor UE2343 (Xanamem)[J]. British Journal of Pharmacology, 2017, 174(5): 396-408. DOI:
10.1111/bph.13699
