Description
Mca-PLAC(p-OMeBz)-WAR(Dpa)-NH
2 is a fluorogenic substrate for matrix metalloproteinase-14 (MMP-14).
1 Upon cleavage by MMP-14, 7-methoxycoumarin-4-acetyl (Mca) is released and its fluorescence can be used to quantify MMP activity. Mca displays excitation/emission maxima of 328/420 nm, respectively.
References
1. Eckhouse, S.R., Akerman, A.W., Logdon, C.B., et al.
Differential membrane type 1 matrix metalloproteinase substrate processing with ischemia-reperfusion: Relationship to interstitial microRNA dynamics and myocardial function J. Thorac. Cardiovasc. Surg. 145(1),267-275(2013).
