Synthesis
(1) Water (348.0 g) was added to a 1000 mL three-necked round-bottomed flask equipped with a mechanical stirrer and a thermometer and cooled to 0°C. Subsequently, sodium borohydride (9.5 g, 0.25 mol) was added and stirred for 20 min. Maintaining the temperature at 5 °C, o-trifluoromethylbenzaldehyde (87.1 g, 0.5 mol) was slowly added dropwise. After the dropwise addition, the reaction temperature was maintained at 10 °C for 1 hour. After completion of the reaction, extraction was carried out by adding methyl tert-butyl ether. The organic phases were combined, washed with saturated brine and concentrated under reduced pressure to no fraction to obtain 2-trifluoromethylbenzenemethanol as a colorless transparent liquid with a purity of >99% and a yield of 90%.
References
[1] Patent: CN106588673, 2017, A. Location in patent: Paragraph 0047; 0048
[2] Patent: CN106699729, 2017, A. Location in patent: Paragraph 0066; 0067
[3] Green Chemistry, 2015, vol. 17, # 9, p. 4537 - 4540
[4] Journal of Organic Chemistry, 2017, vol. 82, # 13, p. 6972 - 6977
