Uses
Rabbit Anti-CLCNKA antibody is suitable for western blot applications at a concentration of 1 μg/ml.
General Description
CLCNKA is a chloride channel, voltage sensitive protein that may regulate renal reabsorption of salts. It may also regulate potassium recycling in the inner ear. Genetic variations in CLCNKA have been linked to cardiac and hypertensive disorders.
Rabbit Anti-CLCNKA antibody recognizes human CLCNKA.
Biochem/physiol Actions
CLCNKA is a member of the CLC family of voltage-gated chloride channels. It is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene.
