Description
CVPA (37710-81-9) is an aquaporin-1 inhibitor (IC50 = 8.1 μM) discovered by molecular docking against the extracellular domain of human aquaporin-1 followed by experimental testing in a Xenopus oocyte swelling assay.1
Uses
TC AQP1 1 is a human aquaoporin-1 (hAQP1) selective inhibitor and is considered to have therapeutic potential towards the potential treatment of glaucoma, brain edema, inflammatory pain and certain types of cancer.
References
[1] DANIEL SEELIGER. Discovery of Novel Human Aquaporin-1 Blockers[J]. ACS Chemical Biology, 2012, 8 1: 249-256. DOI:
10.1021/cb300153z