Description
BIBF 1202 is an active metabolite of the VEGFR, FGFR, and PDGFR inhibitor BIBF 1120 (nintedanib; ). It is formed from BIBF 1120 by intracellular esterases. BIBF 1202 inhibits VEGFR2 with an IC
50 value of 62 nM.
Uses
Nintedanib Carboxylic Acid is a related compound of Intedanib (I666650), an indolinone derivative that inhibits angiokinase and an antitumor agent.
References
[1] FRANK HILBERG. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy.[J]. Cancer research, 2008, 68 12: 4774-4782. DOI:
10.1158/0008-5472.can-07-6307[2] DAN LIN . Simultaneous determination of nintedanib and its metabolite by UPLC–MS/MS in rat plasma and its application to a pharmacokinetic study[J]. Journal of pharmaceutical and biomedical analysis, 2016, 117: Pages 173-177. DOI:
10.1016/j.jpba.2015.08.024
