Synthesis
In 100 ml of toluene add 25 ml of triethylamine, add 12.3 g of 2-methylimidazole, heating to 60 ~ 65 ?? C, dissolved clear at this temperature slowly added 16.7 g of chlorinated isobutane dropwise, dropwise completion of the 60 ~ 65 ?? C holding time of 3 hours, 3 hours after a slow increase in temperature to 100 ~ 110 ?? C, and then held at this temperature for 5 hours, holding time completion of the cooled to 10 ?? C or less, filtration , the filtrate was distilled and 13 g of 96-98??C (4.5 mmHg) fraction was collected as 1-isobutyl-2-methylimidazole. The molar yield of the method was 63% in terms of 2-methylimidazole.
