Description
8-iso-17-phenyl trinor Prostaglandin F2α (8-iso-17-phenyl trinor PGF2α) is the C-8 epimer of bimatoprost (free acid), a metabolically stable analog of PGF2α. Bimatoprost (free acid) binds to the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2α.1 At the rat recombinant FP receptor expressed in CHO cells bimatoprost inhibits PGF2α binding with a Ki of 1.1 nM.2 There are no published studies of the pharmacological properties of 8-iso-17-phenyl trinor PGF2α.WARNING This product is not for human or veterinary use.
References
[1] ANIL K. BALAPURE . Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2α receptor[J]. Biochemical pharmacology, 1989, 38 14: Pages 2375-2381. DOI:
10.1016/0006-2952(89)90478-4[2] S. LAKE . Cloning of the rat and human prostaglandin F2α receptors and the expression of the rat prostaglandin F2α receptor[J]. FEBS Letters, 1994, 355 3: Pages 317-325. DOI:
10.1016/0014-5793(94)01198-2
