Description
Prostaglandin F
2α (PGF
2α) drives luteolysis and smooth muscle contraction by activating the FP receptor. Stable, lipophilic analogs of PGF
2α are used to modulate luteolysis and treat glaucoma. 16-
phenoxy tetranor Prostaglandin F
2α (16-
phenoxy tetranor PGF
2α) is a metabolically stable form of PGF
2α containing a 16-
phenoxy group at the ω-
terminus. It binds to the FP receptor on ovine luteal cells with much greater affinity (440%) than PGF
2α. 16-
phenoxy tetranor PGF
2α methyl ester is a lipophilic analog of 16-
phenoxy tetranor PGF
2α. Methyl esters of PGs serve as prodrugs, as they are efficiently hydrolyzed in certain tissues to generate the bioactive free acid.
