AKOS AU36-M554

Synthesis

To a solution of 8-hydroxy quinoline (0.5 mole) in dry acetone (150 mL), ethyl chloroacetate (0.60 mole) were added followed by anhydrous K₂CO₃ (1.0 mole). After reflux for 20 hour the solvent was removed and the reaction mixture was treated with water, extracted with benzene several times and the collected organic layer was dried on anhydrous Na₂SO₄, filtered and evaporated to give Ethyl (quinolin-8-yloxy) acetate(AKOS AU36-M554).