Description
Unc-51-like autophagy activating kinase 1 (ULK1), also known as autophagy-related 1 homolog (ATG1), is a kinase involved in initiating autophagy.1,2 It is composed of an N-terminal kinase domain, a proline serine-rich domain, and two C-terminal microtubule-interacting and transporter (MIT) domains.2 ULK1 forms a complex with ATG12, ATG5, and ATG15L1 to sequester cargo in autophagosomes prior to transport to and fusion with lysosomes.1,3 It is activated when AMP-activated protein kinase (AMPK) phosphorylates Ser317 and Ser777 in response to low nutrient availability and deactivated when mTORC1 phosphorylates Ser757.4,5 ULK1 phosphorylates and deactivates STING in response to STING-induced increases in levels of cyclic dinucleotides.6 Cayman's ULK1 (Phospho-Ser757) Rabbit Monoclonal Antibody (Clone RM488) can be used for Western blot (WB).WARNING This product is not for human or veterinary use.
