Agcknffwktftsc (disulfide bridge: 3-14), acetate salt

Description

Somatostatin-14 is a natural cyclic peptide hormone derived from the preprohormone, somatostatin. It is a somatostatin (SST) receptor agonist that binds to SST₁, SST₂, SST₃, SST₄, and SST₅ (IC₅₀s = 0.22, 0.10, 0.28, 1.23, and 0.30 nM, respectively, in CCL39 cells expressing human recombinant receptors). It inhibits cAMP accumulation induced by forskolin in CCL39 cells expressing human recombinant SST₁, SST₂, SST₃, SST₄, and SST₅ (EC₅₀s = 6.16, 4.37, 17.38, 2.95, and 4.67 nM, respectively). Somatostatin-14 inhibits the release of growth hormone, prolactin, thyrotropin, glucagon, and insulin, as well as other signaling molecules.

References

[1] D J HADJIDAKIS. Differences between somatostatin-28 and somatostatin-14 with respect to their biological effects in healthy humans and acromegalics.[J]. Clinical physiology and biochemistry, 1986, 4 6: 372-383.
[2] S SIEHLER  D H  K Seuwen. Characterisation of human recombinant somatostatin receptors. 1. Radioligand binding studies.[J]. Naunyn-Schmiedeberg’s archives of pharmacology, 1999, 360 5: 488-499. DOI: 10.1007/s002109900141
[3] S SIEHLER  D H. Characterisation of human recombinant somatostatin receptors. 3. Modulation of adenylate cyclase activity.[J]. Naunyn-Schmiedeberg’s archives of pharmacology, 1999, 360 5: 510-521. DOI: 10.1007/s002109900143
[4] GILLIES G. Somatostatin: the neuroendocrine story.[J]. Trends in pharmacological sciences, 1997, 18 3: 87-95. DOI: 10.1016/s0165-6147(96)01032-2
[5] IAN M P JOSEPH. A model for integrative study of human gastric acid secretion.[J]. Journal of applied physiology, 2003, 94 4: 1602-1618. DOI: 10.1152/japplphysiol.00281.2002