2-Chlorotritylchloride resin

Uses

2-Chlorotrityl chloride resin is an extremely versatile, acid-labile resin for the solid phase immobilization of carboxylic acids, alcohols, phenols and amines, imidazoles, and hydroxylamines. Release these functionalities is generally achieved using 1-50% TFA in DCM containing 5% TIS. However, carboxylic acids can also be cleaved from this support with AcOH/TFE/DCM,0.5% TFA in DCM, or HFIP in DCM.

Definition

100-200 mesh, 1% DVB Typical substitution levels range from 0.8 mmol/g to 1.5 mmol/g. Other substitutions, mesh sizes or crosslinking are available by request.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis