3-amino-3-deoxy-D-glucose hydrochloride

Description

Kanosamine, a constituent of kanamycin, is an antibiotic produced by Streptomyces and Bacillus that can inhibit cell wall synthesis in plant-pathogenic oomycetes (MIC = 25 μg/ml for P. medicaginis M2913) and certain fungi as well as some bacterial species (MIC = 400 μg/ml for S. aureus). It has been explored as an alternative and/or supplement to synthetic pesticides and genetic resistance of crop plants for the management of plant disease.

Uses

An antibiotic which inhibits the growth of Saccharomyces cerevisiae and a range of human pathogenic fungi, including Candida albicans.

References

[1] milner j l, silo-suh l, lee j c, et al. production of kanosamine by bacillus cereus uw85[j]. applied and environmental microbiology, 1996, 62(8): 3061-3065.
[2] dolak l a, castle t m, dietz a, et al. 3-amino-3-deoxyglucose produced by a streptomyces sp[j]. the journal of antibiotics, 1980, 33(8): 900-901.
[3] janiak a m, milewski s. mechanism of antifungal action of kanosamine[j]. medical mycology, 2001, 39(5): 401-408.