Description
Diclofenac-d
4 is intended for use as an internal standard for the quantification of diclofenac (Item Nos.
70680 |
22983) by GC- or LC-MS. Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC
50s = 0.9-2.7 and 1.5-20 μM, for human COX-1 and COX-2, respectively). It is also an active metabolite of diclofenac methyl ester and diclofenac amide . Diclofenac inhibits release of arachidonic acid (Item Nos.
90010 |
90010.1 |
10006607) induced by A23187 in isolated rat peritoneal neutrophils and macrophages (IC
50s = 60 and 10 μM, respectively). Transdermal administration of diclofenac inhibits carrageenan-induced paw edema in rats. Formulations containing diclofenac have been used in the treatment of pain associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
Chemical Properties
Off-White Crystalline Solid
Uses
Labeled Diclofenac, a nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor.
92% overall isotopic purity. A representative lot was 75% d4, 23% d3 and 2 % d2
Uses
Labelled Diclofenac, a nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor.
Uses
Labelled Diclofenac is a known nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor.
References
[1] O LANEUVILLE. Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs.[J]. Journal of Pharmacology and Experimental Therapeutics, 1994, 271 2: 927-934.
[2] SHABBIR LOBO. Evaluation of diclofenac prodrugs for enhancing transdermal delivery.[J]. Drug Development and Industrial Pharmacy, 2014, 40 3: 425-432. DOI:
10.3109/03639045.2013.767828[3] JEAN LEANDRO DOS SANTOS. Pharmacological evaluation and preliminary pharmacokinetics studies of a new diclofenac prodrug without gastric ulceration effect.[J]. International Journal of Molecular Sciences, 2012, 13 11: 15305-15320. DOI:
10.3390/ijms131115305[4] HIMANSHU V. KOTHARI Edmond C K Warren H Lee. An alternate mechanism for regulation of leukotriene production in leukocytes: studies with an anti-inflammatory drug, sodium diclofenac[J]. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1987, 921 3: Pages 502-511. DOI:
10.1016/0005-2760(87)90078-6[5] PRIYANKA ARORA Biswajit M. Design, development, physicochemical, and in vitro and in vivo evaluation of transdermal patches containing diclofenac diethylammonium salt[J]. Journal of pharmaceutical sciences, 2002, 91 9: 2076-2089. DOI:
10.1002/jps.10200
