ANTI-GLUTAMATE RECEPTOR N-METHYL-D-ASPARTATE RECEPTOR NR1] [SPLICE VARIANT INSERT C1

Uses

Anti-Glutamate Receptor NMDAR1 (NR1) (Splice Variant Insert C1) antibody is suitable for immunohistochemistry (frozen sections) at a dilution of 1:1000-1:2000 and western blot at 1:1000 dilution using r at and mouse tissue.

Biological Activity

NMDA receptors (NMDAR) are glutamate-gated ion channels. It is sensitive to N-methyl-D-aspartate (NMDA) and consists of several homologous subunits (NMDAR1). NMDAR is highly expressed in the central nervous system and involved in excitatory synaptic transmission as well as synaptic plasticity. The activity of NMDA receptors are modulated by glycine. It exhibits high calcium permeability and unique voltage-dependent sensitivity to magnesium. It has been reported th at phosphorylated NMDA receptors may regulate their function and play a role in many forms of synaptic plasticity such as long-term potentiation.