Biological Activity
N-3-oxo-pentanoyl-L-Homoserine lactone is a chain-shortened derivative of the bacterial quorum sensing signaling molecule N-3-oxo-octanoyl-L-homoserine lactone .1 It inhibits binding of the autoinducer N-3-oxo-hexanoyl homoserine lactone to E. coli containing the transcription factor LuxR when used at a concentration of 230 nM.2 It acts as an autoinducer to activate the V. fischeri luminescence system in E. coli when used at concentrations ranging from 20 to 200 nM.
References
1.Chhabra, S.R., Stead, P., Bainton, N.J., et al.Autoregulation of carbapenem biosynthesis in Erwinia carotovora by analogues of N-(3-oxohexanoyl)-L-homoserine lactoneJ. Antibiot. (Tokyo)46(3)441-454(1993)
2.Schaefer, A.L., Hanzelka, B.L., Eberhard, A., et al.Quorum sensing in Vibrio fischeri: Probing autoinducer-LuxR interactions with autoinducer analogsJ. Bacteriol.178(10)2897-2901(1996)
