L-Phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]-

Uses

Fmoc-L-Photo-Phe-OH is a diazirine-containing, Fmoc-protected phenylalanine amino acid and multifunctional photo-crosslinker. Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (～360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An unprotected version is also available as 907340.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis