PF-3893787 hydrochloride

Biological Activity

Adriforant hydrochloride (PF-3893787 hydrochloride) is a novel histamine H4 receptor affinity antagonist (Ki=2.4 nM) and a functional H4 receptor antagonist (Ki=1.56 nM).

in vitro

Adriforant is tested and observed binding K _i =2.4 nM and functional K _i =1.56 nM for H4R. Data from functional assays produce convergent projections of the free plasma efficacious concentration and Adriforant (Compound 13) is fast on/fast off on rhH4R.

target