Description
10,13-epoxy-10,12-Octadecadienoic acid is a furan fatty acid produced by oxidation of 10(E),12(Z)-conjugated linoleic acid .
1,2 It upregulates the expression of PLIN2, TPD52L2, and SEC13, which are involved in the formation of lipid droplets, and downregulates a variety of genes involved in general cellular processes in Caco-2 cells.
2 10,13-epoxy-10,12-Octadecadienoic acid is cytotoxic to Caco-2 and HepG2 cells when used concentrations greater than or equal to 100 μM.
References
1. Yurawecz, M.P., Hood, J.K., Mossoba, M.M., et al.
Furan fatty acids determined as oxidation products of conjugated octadecadienoic acid Lipids 30(7),595-598(1995).
2. Lengler, I., Buhrke, T., Scharmach, E., et al.
In-vitro toxicological and proteomic analysis of furan fatty acids which are oxidative metabolites of conjugated linoleic acids Lipids 47(11),1085-1097(2012).
