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Betamethasone 17-valerate

Betamethasone 17-valerate Structure
Betamethasone 17-valerate
  • CAS No.2152-44-5
  • Chemical Name:Betamethasone 17-valerate
  • CBNumber:CB1317879
  • Molecular Formula:C27H37FO6
  • Formula Weight:476.58
  • MOL File:2152-44-5.mol
Betamethasone 17-valerate Property
  • Melting point: :183-184°
  • alpha  :D +77° (dioxane)
  • Boiling point: :598.9±50.0 °C(Predicted)
  • Density  :1.1174 (estimate)
  • storage temp.  :2-8°C
  • solubility  :Practically insoluble in water, freely soluble in acetone and in methylene chloride, soluble in ethanol (96 per cent).
  • form  :neat
  • pka :12.90±0.70(Predicted)
  • Merck  :13,1183
  • BRN  :4240001
  • InChIKey :SNHRLVCMMWUAJD-SUYDQAKGSA-N
  • CAS DataBase Reference :2152-44-5(CAS DataBase Reference)
  • FDA UNII :9IFA5XM7R2
  • EPA Substance Registry System :.beta.-Methasone 17-valerate (2152-44-5)
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :48
  • Safety Statements  :22-24/25
  • RTECS  :TU3835000
  • HS Code  :2937229000
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
Betamethasone 17-valerate Price More Price(14)
  • Brand: Sigma-Aldrich
  • Product number: B0515
  • Product name : Betamethasone 17-valerate
  • Purity: 
  • Packaging: 25mg
  • Price: $82.6
  • Updated: 2021/03/22
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  • Brand: Sigma-Aldrich
  • Product number: Y0001027
  • Product name : Betamethasone valerate for system suitability
  • Purity: European Pharmacopoeia (EP) Reference Standard
  • Packaging: 
  • Price: $190
  • Updated: 2021/03/22
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  • Brand: Sigma-Aldrich
  • Product number: B1054000
  • Product name : Betamethasone 17-valerate
  • Purity: European Pharmacopoeia (EP) Reference Standard
  • Packaging: 
  • Price: $190
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 1069007
  • Product name : Betamethasone valerate
  • Purity: United States Pharmacopeia (USP) Reference Standard
  • Packaging: 200mg
  • Price: $366
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 25640
  • Product name : Betamethasone 17-valerate
  • Purity: ≥98%
  • Packaging: 50mg
  • Price: $93
  • Updated: 2021/03/22
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Betamethasone 17-valerate Chemical Properties,Usage,Production

  • Chemical Properties White Solid
  • Originator Valisone,Schering,US,1967
  • Uses Betamethasone 17-Valerate is a corticosteroid with anti-inflammatory properties. Topical application of Betamethasone 17-Valerate has been shown to inhibit heat-induced vasodilatation in man.
  • Uses Antiepileptic non-selective phosphodiesterase inhibitor
  • Uses Betamethasone 17-valerate is a glucocorticoid with anti-inflammatory and immunosuppressive activity.
  • Uses A potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties
  • Definition ChEBI: A steroid ester that is betamethasone in which the hydroxy group at the 17alpha position has been converted to the corresponding pentanoate ester.
  • Indications Betamethasone valerate (Psorion, Beta-Val, Luxiq) is a synthetic fluorinated corticosteroid.
  • Manufacturing Process The valerate is made from betamethasone as a starting material as follows: A suspension of 9α-fluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene- 3,20-dione(betamethasone) (2 grams) in sodium dried benzene (500 ml) was distilled vigorously for a few minutes, toluene-p-sulfonic acid monohydrate (30 mg) and methyl orthovalerate (5 ml) were added and distillation was continued for 10 minutes. The mixture was then boiled under reflux for 1.5 hours after which time unreacted betamethasone alcohol (400 mg) was removed by filtration. The benzene solution was treated with solid sodium .bicarbonate and a few drops of pyridine, filtered and evaporated to dryness at about 50°C. The residue, in ether, was filtered through grade III basic alumina (20grams) to remove traces of unreacted betamethasone alcohol, the ether removed in vacuo and the residue of crude betamethasone 17,21- methyl orthovalerate was treated with acetic acid (20ml) and a few drops of water and left overnight at room temperature.
    The acetic acid solution was poured into water (100 ml) and extracted with chloroform. The chloroform extracts were washed in turn with water, saturated sodium bicarbonate solution and water, dried and evaporated in vacuo. The residual gum was triturated with ether and a white crystalline solid (1.16 grams) isolated by filtration. Recrystallization from ether (containing a small amount of acetone)-petroleum ether gave 9α-fluoro-11β,21-dihydroxy-16β- methyl-17α-valeryloxypregna-1,4-diene-3,20-dione (871 mg) as fine needles.
  • brand name Betatrex (Savage); Luxiq (Connetics); Valisone (Schering).
  • Therapeutic Function Corticosteroid
Betamethasone 17-valerate Preparation Products And Raw materials
Raw materials
Preparation Products
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2152-44-5, Betamethasone 17-valerateRelated Search:
  • pregna-1,4-diene-3,20-dione,9-fluoro-11,21-dihydroxy-16-methyl-17-((1-oxopenty
  • 9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-valerate
  • 9ALPHA-FLUORO-16BETA-METHYLPREDNISOLONE 17-VALERATE
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  • 1,4-PREGNADIENE-11BETA,17ALPHA,21-TRIOL-9ALPHA-FLUORO-16BETA-METHYL-3,20-DIONE 17-VALERATE
  • 1,4-pregnadiene-11b,17a,21-triol-9a-fluoro-16b-methyl-3,20-dione 17-valerate
  • 9α-Fluoro-16β-methylprednisolone 17-valerate, Betnovate, 9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17-valerate, 1,4-Pregnadiene-11β,17α,21-triol-9α-fluoro-16β-methyl-3,20-dione 17-valerate
  • BetaMethasone valerate (Betnovate)
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  • Deviphos
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  • Valison
  • [(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] pentanoate
  • [(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-17-(2-hydroxyethanoyl)-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] pentanoate
  • valeric acid [(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-17-glycoloyl-11-hydroxy-3-keto-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] ester
  • Betamethasone 17-valerate,1,4-Pregnadiene-11β,17α,21-triol-9α-fluoro-16β-methyl-3,20-dione 17-valerate, 9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17-valerate, 9α-Fluoro-16β
  • Betamethasone Valerate (200 mg)
  • Betamethasone Valerate (200 mg)K0C3300.997mg/mg(ai)
  • Betamethasone 17-val
  • BetaMethasone valerate (Betnovate, Celestone)
  • (11β,16β)-9-Fluoro-11,21-dihydroxy-16-Methyl-17-[(1-oxopentyl)oxy]pregna-1,4-diene-3,20-dione
  • 9α-Fluo
  • 9α-Fluoro-16β-Methylprednisolone 17-Valerate
  • BETHAMETASONE VALERATE
  • (8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-triMethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl pentanoate
  • BetaMethasone valerate 17-
  • betnovateat
  • celestoderm
  • 1,4-PREGNADIEN-9-ALPHA-FLUORO-16-BETA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 17-VALERATE
  • BEDERMIN
  • BETNESOL-V
  • BETNEVAL
  • BETNOVATE
  • BETAMETHASONE VALERATE
  • BETAMETHASONE 17ALPHA-VALERATE
  • BETAMETHASONE 17A-VALERATE
  • BETAMETHASONE 17-VALERATE
  • BETAMETHASONEVALERATE,MICRONIZEDPOWDER,USP
  • 9α-Fluoro-11β,21-dihydroxy-16β-methyl-17α-valeryloxypregna-1,4-diene-3,20-dione
  • Beta-Val
  • Betoid
  • Bextasol
  • Celestan V
  • Celestane V
  • Celestoderm V
  • Celeston valerate
  • Dermosol
  • Dermovaleas
  • Ecoval 70
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16β-methyl-, 17-valerate (7CI, 8CI)
  • Rinderon V
  • Stanoval
  • Tokuderm
  • Valeric acid, 17-ester with 9-fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione (8CI)
  • betamethasone pentanoate
  • 1,4-pregnadiene-11β,17α,21-triol-9α-fluoro-16β-methyl-3,20-dione 17-valerate
  • BETAMETHASONE 17-VALERATE VETRANAL, 250
  • BETAMETHASONE 17-VALERATE BP USP