TH287 (hydrochloride)
- Product NameTH287 (hydrochloride)
- CAS1638211-05-8
- CBNumberCB13041470
- MFC11H11Cl3N4
- MW305.59
- MDL NumberMFCD28127273
- MOL File1638211-05-8.mol
Chemical Properties
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
TH287 (hydrochloride) Price
| Product number | Packaging | Price | Product description | Buy |
|---|---|---|---|---|
| Crysdot CD31003098 | 5mg | $52 | TH287 hydrochloride 98+% |
Buy |
| Crysdot CD31003098 | 10mg | $70 | TH287 hydrochloride 98+% |
Buy |
| DC Chemicals DC24091 | 10mg | $96 | TH287 hydrochloride >98% |
Buy |
| Crysdot CD31003098 | 50mg | $281 | TH287 hydrochloride 98+% |
Buy |
| DC Chemicals DC24091 | 50mg | $384 | TH287 hydrochloride >98% |
Buy |
TH287 (hydrochloride) Chemical Properties,Usage,Production
Description
TH287 hydrochloride is a potent inhibitor of MTH1 (NUDT1) with an IC50 value of 0.8 nM, less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.IC50 value: 0.8 nM [1]Target: MTH1 inhibitorTH287 is considered a new target for cancer therapy. TH287 is highly selective towards MTH1, with no relevant inhibition of other members of the nudix protein family. TH287 has been shown to selectively kill a variety of cancer cell lines, but is rapidly metablized, so not as useful for in vivo studies.
References
[1]. Gad H, et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 2014 Apr 10;508(7495):215-21.
Preparation Products And Raw materials
TH287 (hydrochloride) Suppliers
Global(17)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 32161 | 58 | |
| 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6312 | 58 | |
| 571-89925085 | sales@amadischem.com | China | 131957 | 58 | |
| 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 | |
| 021-65675885 18964387627 |
info@efebio.com | China | 9806 | 58 | |
| +1-800-259-7612 | info@musechem.com | United States | 4660 | 60 | |
| 15911056312 | liming@bio-fount.com | China | 9729 | 58 | |
| 021-58447131 13564518121 |
sales@dcchemicals.com | China | 9409 | 58 | |
| +1 (732)236-3202 | sales@cckinase.com | United States | 2738 | 58 | |
| 13969155946 | 1461866103@qq.com | China | 16111 | 58 |
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